Fresh analysis suggests that patients who come off new slimming jabs like Wegovy and Mounjaro may regain reduced body mass much more quickly than those who stop traditional diet and exercise plans.
Research printed in a prominent health publication points out that while overweight people frequently drop substantial amounts of their total mass while using the jabs, the mass returns at an average rate of 0.8 kg per month once they quit.
"Users purchasing these medications must be cognizant of the potential of fast weight regain when the treatment is stopped," cautioned expert Dr. Susan Jebb.
Such speed of regain means a return to starting mass within about 18 months.
Comparing Approaches
The study, which reviewed dozens of studies involving over 9,000 of participants, compared the outcomes of the injectable medications with older methods.
Researchers note that individuals who shed pounds through lifestyle changes alone typically see a more gradual creep back—approximately 0.1 kg a month—post-intervention.
Understanding the Quick Rebound
Experts propose the way of the drugs accounts for the amplified regain.
GLP-1 drugs mimic a natural hormone called GLP-1, which helps regulate feelings of fullness.
"Sustained high doses of the hormone levels several times higher than the body's typical production could lead to the system to produce less of its endogenous hormone, and could diminish responsiveness to its actions," said Dr. Adam Collins, a nutrition specialist.
"Stopping of this medication leads to hunger is uncontrolled, making excessive eating much more probable."
A Lifelong Issue?
Health authorities advise the jabs for individuals with obesity-related medical conditions, alongside recommended diet and exercise modifications.
A number of clinicians say that, considering the likelihood of relapse, the treatment should be considered life-long.
This view is supported by pharmaceutical companies, who state that the results "highlight the chronic character of obesity," similar to managing diseases like diabetes.
User Accounts
People who have stopped the medication report a intense resurgence of appetite.
"It was like a trigger activating and you become starving," recalled an individual.
This difficulty is compounded if individuals have not developed permanent lifestyle or habit changes during treatment.
Significant Interest
Recent estimates indicate that a significant number of people in the UK have used these injections in the last 12 months, with desire continuing to grow.
- Use is greater among women compared to men.
- The 40s and 50s age group shows the highest usage rates.
- Many access the drugs through private prescriptions rather than public health services.
Finally, researchers caution that while the jabs are effective agents for weight loss, they are not a magic cure and lasting health benefits likely depends on ongoing behavioural management.
